Exosomes

During a chronic injury, damaged tissue can be in an unregulated inflammatory state in which the body’s own stem cells are unable to finish the healing process. In this scenario, exosomes reduce inflammation in order to create a therapeutic environment to allow healing of the area to continue. The exosomes that are used by Calvin Medical are donated from human MSC’s (Mesenchymal Stem Cells) and then purified with a proprietary process leaving no actual genetic material of the donor; meaning no nucleus or DNA is present.

Exosomes are a supplementary option during a Stem Cell or Platelet Rich Plasma procedure.

Alpha 2 Macroglobulin (A2M) / Interleukin-1-Receptor Antagonist Protein (IRAP):

Contained within blood plasma, A2M and IRAP are naturally occurring proteins that lower inflammation and can help to slow cartilage and bone breakdown. A2M and IRAP are obtained during a stem cell or PRP procedure and are an excellent option for patients who experience early degenerative changes with the goal to prevent the progression of arthritis.

Both A2M and IRAP are supplementary options during a Stem Cell or Platelet Rich Plasma procedure.

Resources:

Exosomes

https://directbiologics.com

A2M / IRAP
Research:
  1. Karli et al. Autologous Regenerative Therapies: Rapid Concentration of Progenitor Cells, Platelets, and Proteins at the Point-of-Care” TERMIS Annual Meeting. (2015) Boston, MA
  2. Monteforte et al. “Autologous Protein Scaffold Isolated from Platelet Poor Plasma in Bone Marrow Concentrate” World Stem Cell Summit. (2016) West Palm Beach, FL.
  3. Cassano, Jennifer M., et al. “Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration.” Knee Surgery, Sports Traumatology, Arthroscopy (2016): 1-10.
  4. Monteforte et al. “Autologous Protein Scaffold Isolated from Platelet Poor Plasma in Bone Marrow Concentrate” World Stem Cell Summit. (2016) West Palm Beach, FL.
  5. Barrientos, Stephan, et al. “Growth factors and cytokines in wound healing.” Wound Repair and Regeneration 16.5 (2008): 585-601.
  6. Wang, Shaowei, et al. “Identification of α2‐Macroglobulin as a Master Inhibitor of Cartilage‐Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis.” Arthritis & rheumatology 66.7 (2014): 1843-1853

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526282/
https://www.ncbi.nlm.nih.gov/pubmed/30609267

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